Effects of the time of antihypertensive drugs administration on the stage of primary open-angle glaucoma in patients with arterial hypertension

• Published in: Blood pressure Vol. 21; no. 4; pp. 240 - 248
• Main Authors: Krasi ska, Beata, Karolczak-Kulesza, Ma gorzata, Krasi ski, Zbigniew, Pawlaczyk-Gabriel, Katarzyna, opatka, Pawe, G uszek, Jerzy, Tykarski, Andrzej
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.08.2012; Taylor & Francis
• Subjects: Adult; Aged; Antihypertensive Agents - administration & dosage; Antihypertensive Agents - therapeutic use; Blood Pressure; Blood Pressure Monitoring, Ambulatory; chronotherapy; Circadian Rhythm; Drug Chronotherapy; Eye - blood supply; Eye - pathology; Female; glaucoma; Glaucoma, Open-Angle - drug therapy; Glaucoma, Open-Angle - pathology; Glaucoma, Open-Angle - physiopathology; Humans; hypertension; Hypertension - drug therapy; Hypertension - physiopathology; hypotensive drugs; Male; Middle Aged; Optic Nerve - blood supply; Optic Nerve - pathology; Orbit - blood supply; Regional Blood Flow; Ultrasonography, Doppler, Color; visual field defects
• ISSN: 0803-7051; 1651-1999
• DOI: 10.3109/08037051.2012.666423

Many patients with glaucoma suffer from arterial hypertension (AH). It has been proved that both AH and low blood pressure (BP) at night are important vascular risk factors for primary open-angle glaucoma (POAG). The aims of this study were to assess the severity of pathological changes within the optic nerve and characteristics of blood flow in selected arteries of the eyeball and orbit in patients with POAG and controlled hypertension, in relation to the time of hypotensive drugs administration. Eighty-eight patients with POAG and treated, controlled hypertension were examined. The patients were divided into two subgroups, consisting of group A (n = 43), in whom hypotensive drugs were dosed only in the morning and group B (n = 45), in whom hypotensive drugs were also taken in the evening. In patients who were taking hypotensive drugs also in the evening (group B), there was a statistically significant lower mean perfusion pressure at night, a greater visual field loss and reduced amplitude of evoked potentials. Our analysis showed significantly worse changes in the parameters relating to the optic nerve in patients taking hypertensive medicines in the evening and also significantly lower perfusion pressures at night.