Viability Criteria during Liver Ex-Situ Normothermic and Hypothermic Perfusion

With the increased use of extended-criteria donors, machine perfusion became a beneficial alternative to cold storage in preservation strategy for donor livers with the intent to expand donor pool. Both normothermic and hypothermic approach achieved good results in terms of mid- and long-term outcom...

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Published inMedicina (Kaunas, Lithuania) Vol. 58; no. 10; p. 1434
Main Authors Melandro, Fabio, De Carlis, Riccardo, Torri, Francesco, Lauterio, Andrea, De Simone, Paolo, De Carlis, Luciano, Ghinolfi, Davide
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2022
MDPI
Subjects
Analysis
Clinical trials
Cold storage
hypothermic machine perfusion
Liver
liver transplantation
Liver transplants
machine perfusion
Methods
normothermic machine perfusion
Practice guidelines (Medicine)
Preservation of organs, tissues, etc
Review
Transplantation
Transplants & implants
viability criteria
Italy
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Summary:With the increased use of extended-criteria donors, machine perfusion became a beneficial alternative to cold storage in preservation strategy for donor livers with the intent to expand donor pool. Both normothermic and hypothermic approach achieved good results in terms of mid- and long-term outcome in liver transplantation. Many markers and molecules have been proposed for the assessment of liver, but no definitive criteria for graft viability have been validated in large clinical trials and key parameters during perfusion still require optimization.In this review, we address the current literature of viability criteria during normothermic and hypothermic machine perfusion and discuss about future steps and evolution of these technologies.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina58101434