Lack of experimental evidence to support mcr-1-positive Escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets

• Published in: International journal of antimicrobial agents Vol. 51; no. 1; pp. 128 - 131
• Main Authors: Viel, Alexis, Henri, Jérôme, Perrin-Guyomard, Agnès, Laroche, Julian, Couet, William, Grégoire, Nicolas, Laurentie, Michel
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2018; Elsevier
• Subjects: Administration, Oral; Animal biology; Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacology; Colistin; Colistin - administration & dosage; Colistin - pharmacology; Drug Resistance, Bacterial - genetics; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - genetics; Escherichia coli Infections - drug therapy; Escherichia coli Infections - microbiology; Escherichia coli Proteins - genetics; Farms; Feces - chemistry; Feces - microbiology; Intestines - microbiology; Life Sciences; mcr-1; Medication; Pharmaceutical sciences; Piglets; Rifampin - pharmacology; Selection; Swine; Veterinary medicine and animal Health; Piglets; Colistin; Escherichia coli; Selection; mcr-1; oral administration; veterinary drug; efficacity; colistine; efficacité; cochon; piglet; administration orale; MCR-1; médicament vétérinaire; colistin
• ISSN: 0924-8579; 1872-7913
• DOI: 10.1016/j.ijantimicag.2017.04.013

•Piglets harbouring mcr-1-positive Escherichia coli were treated orally with colistin.•Recommended European dosage and double dosage of colistin were given by gavage.•No selective effect of colistin on E. coli was observed in our experiments. In this study, we assessed the selective effect of colistin administered orally to healthy weaned piglets harbouring an intestinal mcr-1-positive Escherichia coli strain. Maximum recommended dose and a higher dose often used in European pig farms were given by gavage. No selection of the mcr-1-positive strain was observed in our controlled conditions, irrespective of the dose. Further investigations in real farming conditions seem necessary.