A highly selective and sensitive fluorescent probe for hypochlorous acid and its lysosome-targetable biological applications

• Published in: Talanta (Oxford) Vol. 174; pp. 234 - 242
• Main Authors: Liu, Chang, Jiao, Xiaojie, He, Song, Zhao, Liancheng, Zeng, Xianshun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2017
• Subjects: 1,8-Naphthalimide; electron transfer; fluorescence; fluorescent dyes; Fluorescent probe; Hypochlorous acid; image analysis; Imaging; Lysosome; monitoring; morpholine; PET; reactive oxygen species; Hypochlorous acid; 1,8-Naphthalimide; Imaging; PET; Fluorescent probe; Lysosome

A novel lysosome-targetable fluorescence probe PT-1 based on a photoinduced electron transfer (PET) mechanism has been designed and synthesized. For comparison, the probe PT-2 without morpholine moiety as a lysosome-directing group was also synthesized and investigated. Probes PT-1 and PT-2 exhibite...