Dietary Sinapic Acid Alleviates Adiposity and Inflammation in Diet-Induced Obese Mice

• Published in: Preventive nutrition and food science Vol. 27; no. 4; pp. 407 - 413
• Main Authors: Yoon, Hye Jin, Yoon, Dae Seong, Baek, Hea Ja, Kang, Beodeul, Jung, Un Ju
• Format: Journal Article
• Language: English
• Published: Korea (South) 한국식품영양과학회 31.12.2022; The Korean Society of Food Science and Nutrition
• Subjects: Original; 식품과학; lipogenesis; inflammation; sinapic acid; insulin resistance; obesity
• ISSN: 2287-1098; 2287-8602
• DOI: 10.3746/pnf.2022.27.4.407

Sinapic acid (SA), a hydroxycinnamic acid, is known to confer protection against oxidative stress, inflammation, diabetes, and liver disease. However, the effectiveness of SA in improving obesity remains obscure. Therefore, this study evaluated anti-obesity efficacy of SA and to elucidate its mechanism of action. Male mice were maintained for 16 weeks on high-fat diet (HFD) alone or with SA (0.004%, w/w) and bodyweight, fat mass, adipocyte size, food intake, and biochemical and molecular markers were evaluated. SA-supplemented mice demonstrated markedly decreased fat mass and adipocyte size compared to unsupplemented group, without any changes in bodyweight and food intake between the two groups. Plasma adipocytokines levels including leptin, resistin, monocyte chemoattractant protein (MCP)-1 and interleukin-6 were also markedly reduced by SA supplementation. SA tended to lower plasma insulin level and improved homeostatic index of insulin resistance and intraperitoneal glucose tolerance test in HFD-induced obese mice. The anti-adiposity effect of SA was maybe owing to down-regulation of the mRNA expression of lipogenic genes, including ( ) , , - , and , and γ, a transcription factor responsible for governing lipid metabolism, in adipose tissues. SA significantly down-regulated pro-inflammatory , , , and mRNA expression in adipose tissue. Thus, SA could be beneficial for the development of functional foods or herbal medications to combat obesity.