A handy and solventless direct route to primary 3-[3-aryl)-1,2,4-oxadiazol-5-yl]propionamides using microwave irradiation

A one-step, simple and straightforward synthesis of the title amides from the corresponding carboxylic acids, urea and imidazole under microwave irradiation is described.

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Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 11; no. 5; pp. 318 - 324
Main Authors Neves Filho, Ricardo A W, Srivastava, Rajendra M
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 09.05.2006
MDPI
Subjects
4-Oxadiazoles
Acids
amides
Amides - chemical synthesis
Analgesics
Carboxylic Acids - chemistry
Chromatography, Thin Layer
imidazole
Magnetic Resonance Spectroscopy
microwave irradiation
Microwaves
Pallets
Propionates - chemistry
Solvents
Spectrophotometry, Infrared
spectroscopy
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Summary:A one-step, simple and straightforward synthesis of the title amides from the corresponding carboxylic acids, urea and imidazole under microwave irradiation is described.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1420-3049
1420-3049
DOI:10.3390/11050318