Effects of Risk Factors and Ki-67 on Rates of Recurrence on Patients Who Have Undergone Liver Transplant for Hepatocellular Carcinoma

• Published in: Transplantation proceedings Vol. 43; no. 10; pp. 3807 - 3812
• Main Authors: Aktas, S, Karakayali, H, Moray, G, Ozdemir, H, Haberal, M
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.12.2011; Elsevier
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Carcinoma, Hepatocellular - chemistry; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - surgery; Chi-Square Distribution; Child; Child, Preschool; Disease-Free Survival; Epidemiology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; General aspects; Humans; Infant; Ki-67 Antigen - analysis; Liver Neoplasms - chemistry; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Liver Neoplasms - surgery; Liver Transplantation - adverse effects; Liver Transplantation - mortality; Male; Medical sciences; Middle Aged; Neoplasm Recurrence, Local; Odds Ratio; Patient Selection; Public health. Hygiene; Public health. Hygiene-occupational medicine; Retrospective Studies; Risk Assessment; Risk Factors; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Survival Analysis; Time Factors; Tissue, organ and graft immunology; Treatment Outcome; Tumor Burden; Turkey; Young Adult; Turkey; Human; Relapse; Digestive system; Liver; Rate; Biological marker; Hepatic disease; Hepatocellular carcinoma; Patient; Transplantation; Malignant tumor; Homotransplantation; Epidemiology; Medicine; Liver cancer; Treatment; Surgery; Risk factor; Ki67 antigen; Digestive diseases; Graft; Cancer
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2011.09.067

Abstract Purpose We investigated the prognostic factors affecting recurrence including Ki-67 among patients who underwent liver transplantation for hepatocellular carcinoma. Materials and Methods The 50 patients with a diagnosis of hepatocellular carcinoma and cirrhosis included those with expanded criteria for hepatocellular carcinoma excluding subjects with major vascular invasion and metastases but not taking into account tumor size and number of tumor nodules. Results Twenty-eight patients had hepatocellular carcinoma characteristics outside the Milan criteria. Nineteen patients had unifocal; 31, multifocal hepatocellular carcinomas. Mean tumor size was 3.2 cm; mean tumor number was 5.06 lesions. Over a mean follow-up of 45.3 ± 22.6 months, we diagnosed, respectively 2 recurrences. Overall 1-, 3-, and 5-year patient survival rates were 95.6%, 88.4%, and 84.8% and disease-free survival rates, 92%, 78.4%, and 71%, respectively. The independent prognostic factors by multivariate analyses were the number of tumors and Ki-67 with a cutoff value of 10%. Conclusion Ki-67 staining percentage represent a marker to select recipients and to follow posttransplant recurrence.