Catalase, carbonic anhydrase and xanthine oxidase activities in patients with mycosis fungoides

• Published in: Journal of enzyme inhibition and medicinal chemistry Vol. 30; no. 2; pp. 212 - 215
• Main Authors: Cengiz, Fatma Pelin, Beyaztas, Serap, Gokce, Basak, Arslan, Oktay, Guler, Ozen Ozensoy
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.04.2015; Informa Healthcare
• Subjects: Carbonic anhydrase; Carbonic Anhydrases - metabolism; Case-Control Studies; catalase; Catalase - metabolism; Erythrocytes - enzymology; Humans; Middle Aged; mycosis fungoides; Mycosis Fungoides - blood; Mycosis Fungoides - enzymology; Skin Neoplasms - blood; Skin Neoplasms - enzymology; xanthine oxidase; Xanthine Oxidase - metabolism; Carbonic anhydrase; mycosis fungoides; xanthine oxidase; catalase
• ISSN: 1475-6366; 1475-6374
• DOI: 10.3109/14756366.2014.908292

Abstract Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. In several studies the relationship between catalase (CAT), human cytosolic carbonic anhydrases (CA; hCA-I and hCA-II) and xanthine oxidase (XO) enzyme activities have been investigated in various types of cancers but carbonic anhydrase, catalase and xanthine oxidase activities in patients with MF have not been previously reported. Therefore, in this preliminary study we aim to investigate CAT, CA and XO activities in patients with MF. This study enrolled 32 patients with MF and 26 healthy controls. According to the results, CA and CAT activities were significantly lower in patients with mycosis fungoides than controls (p < 0.001) (p < 0.001). There was no significant difference in XO activity between patient and control group (p = 0.601). Within these findings, we believe these enzyme activity levels might be a potentially important finding as an additional diagnostic biochemical tool for MF.