Donor-associated malignancy in kidney transplant patients

Skin cancer cells with donor genotype have been identified in allogeneic transplant patients; however, the donor contribution to the recipient's epithelial malignancy remains to be established. In this issue of the JCI, Verneuil et al. provide the first evidence for donor contribution to the ma...

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Bibliographic Details
Published inThe Journal of clinical investigation Vol. 123; no. 9; pp. 3708 - 3709
Main Authors Cui, Cai-Bin, Gerber, David A
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 01.09.2013
Subjects
Biomedical research
Bone marrow
Carcinoma, Squamous Cell - etiology
Causes of
Cell adhesion & migration
Colleges & universities
Health aspects
Humans
Kidney Transplantation - adverse effects
Kidneys
Mitochondrial DNA
Mortality
Mutation
Organ transplant recipients
Skin cancer
Skin Neoplasms - etiology
Squamous cell carcinoma
Transplantation
Transplants & implants
United States
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Summary:Skin cancer cells with donor genotype have been identified in allogeneic transplant patients; however, the donor contribution to the recipient's epithelial malignancy remains to be established. In this issue of the JCI, Verneuil et al. provide the first evidence for donor contribution to the malignant epithelium of skin squamous cell carcinoma in a kidney transplant recipient. This case report may have important implications for cancer research and clinical care of long-surviving kidney transplant patients.
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ISSN:0021-9738
1558-8238
DOI:10.1172/JCI70438