Anxiety Shapes Amygdala-Prefrontal Dynamics During Movie Watching

A well-characterized amygdala–dorsomedial prefrontal circuit is thought to be crucial for threat vigilance during anxiety. However, engagement of this circuitry within relatively naturalistic paradigms remains unresolved. Using an open functional magnetic resonance imaging dataset (Cambridge Centre...

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Published inBiological psychiatry global open science Vol. 3; no. 3; pp. 409 - 417
Main Authors Kirk, Peter A., Holmes, Avram J., Robinson, Oliver J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2023
Elsevier
Subjects
Amygdala
Anxiety
Archival Report
fMRI
Naturalistic
Vigilance
fMRI
Vigilance
Anxiety
Naturalistic
Amygdala
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Summary:A well-characterized amygdala–dorsomedial prefrontal circuit is thought to be crucial for threat vigilance during anxiety. However, engagement of this circuitry within relatively naturalistic paradigms remains unresolved. Using an open functional magnetic resonance imaging dataset (Cambridge Centre for Ageing Neuroscience; n = 630), we sought to investigate whether anxiety correlates with dynamic connectivity between the amygdala and dorsomedial prefrontal cortex during movie watching. Using an intersubject representational similarity approach, we saw no effect of anxiety when comparing pairwise similarities of dynamic connectivity across the entire movie. However, preregistered analyses demonstrated a relationship between anxiety, amygdala-prefrontal dynamics, and anxiogenic features of the movie (canonical suspense ratings). Our results indicated that amygdala-prefrontal circuitry was modulated by suspense in low-anxiety individuals but was less sensitive to suspense in high-anxiety individuals. We suggest that this could also be related to slowed habituation or amplified anticipation. Moreover, a measure of threat-relevant attentional bias (accuracy/reaction time to fearful faces) demonstrated an association with connectivity and suspense. Overall, this study demonstrated the presence of anxiety-relevant differences in connectivity during movie watching, varying with anxiogenic features of the movie. Mechanistically, exactly how and when these differences arise remains an opportunity for future research.
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AJH and OJR contributed equally to this work as joint senior authors.
ISSN:2667-1743
2667-1743
DOI:10.1016/j.bpsgos.2022.03.009