A review of the chemical modification techniques of starch

•Techniques for the chemical modification of starch appraised.•Oxidation, esterification and etherification modification methods discussed.•The implications on drug delivery systems design analyzed.•The potential for starch-based polymer`s in drug delivery application presented. Starch is a naturall...

Full description

Saved in:
Bibliographic Details
Published inCarbohydrate polymers Vol. 157; pp. 1226 - 1236
Main Authors Masina, Nonhlanhla, Choonara, Yahya E., Kumar, Pradeep, du Toit, Lisa C., Govender, Mershen, Indermun, Sunaina, Pillay, Viness
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 10.02.2017
Subjects
Carbohydrate functionalization
Chemical modification
clinical trials
composite polymers
Delivery system design
Drug delivery
drug delivery systems
esterification
modified starch
oxidation
physicochemical properties
Physiochemical properties
Starch
Chemical modification
Drug delivery
Carbohydrate functionalization
Physiochemical properties
Starch
Delivery system design
Online AccessGet full text

Cover

More Information
Summary:•Techniques for the chemical modification of starch appraised.•Oxidation, esterification and etherification modification methods discussed.•The implications on drug delivery systems design analyzed.•The potential for starch-based polymer`s in drug delivery application presented. Starch is a naturally occurring storage copolymer with unique physicochemical properties. There are, however, some key structural properties of starch that can be modified in order to functionalize the copolymer to meet specific requirements. Specifically, the chemical modification of starch provides a variety of physicochemical benefits, some of which have been used previously to functionalize preformed drug delivery systems. Of the three main chemical modification methods reviewed (namely: oxidation, esterification and etherification), surface chemical oxidation introduces more pertinent physicochemical properties that increase overall drug delivery system efficacy and applicability. Surface oxidation evidently is the more preferable chemical modification method of pre-formed starch particles and has the greatest potential for further development when compared to the other reviewed chemical modification methods. The use of modified starch in clinical trials as well as the potential future implications of these systems is also included in this review.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0144-8617
1879-1344
1879-1344
DOI:10.1016/j.carbpol.2016.09.094