Predicting dementia using socio-demographic characteristics and the Free and Cued Selective Reminding Test in the general population

• Published in: Alzheimer's research & therapy Vol. 9; no. 1; p. 21
• Main Authors: Mura, Thibault, Baramova, Marieta, Gabelle, Audrey, Artero, Sylvaine, Dartigues, Jean-François, Amieva, Hélène, Berr, Claudine
• Format: Journal Article
• Language: English
• Published: England BioMed Central 23.03.2017
• Subjects: Age; Age Distribution; Aged; Aged, 80 and over; Alzheimer's disease; Causality; Comorbidity; Cues; Dementia; Dementia - diagnosis; Dementia - epidemiology; Demographics; Education; Educational Status; Female; France - epidemiology; Funding; Humans; Life Sciences; Longitudinal Studies; Male; Memory; Memory Disorders - diagnosis; Memory Disorders - epidemiology; Mental Status and Dementia Tests; Partnership agreements; Population; Prevalence; Prognosis; Proportional Hazards Models; Reproducibility of Results; Risk Assessment; Semantics; Sensitivity and Specificity; Sex Distribution; Sociodemographics; Socioeconomic Factors; Early clinical trial; Alzheimer disease; Prediction; prodromal Alzheimer disease; Dementia; preclinical Alzheimer disease
• ISSN: 1758-9193; 1758-9193
• DOI: 10.1186/s13195-016-0230-x

Our study aimed to determine whether the consideration of socio-demographic features improves the prediction of Alzheimer's dementia (AD) at 5 years when using the Free and Cued Selective Reminding Test (FCSRT) in the general older population. Our analyses focused on 2558 subjects from the prospective Three-City Study, a cohort of community-dwelling individuals aged 65 years and over, with FCSRT scores. Four "residual scores" and "risk scores" were built that included the FCSRT scores and socio-demographic variables. The predictive performance of crude, residual and risk scores was analyzed by comparing the areas under the ROC curve (AUC). In total, 1750 subjects were seen 5 years after completing the FCSRT. AD was diagnosed in 116 of them. Compared with the crude free-recall score, the predictive performances of the residual score and of the risk score were not significantly improved (AUC: 0.83 vs 0.82 and 0.88 vs 0.89 respectively). Using socio-demographic features in addition to the FCSRT does not improve its predictive performance for dementia or AD.