Treatment of Acute Graft-vs-Host Disease After Simultaneous Pancreas-Kidney Transplantation: A Case Report

Abstract Whereas neutropenia is common after solid-organ transplantation, graft-vs-host disease is unusual, especially after simultaneous pancreas-kidney transplantation. Most cases reported in the literature give few details of treatment approach, and all were fatal. A 45-year-old man with diabetes...

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Bibliographic Details
Published inTransplantation proceedings Vol. 42; no. 9; pp. 3894 - 3897
Main Authors Osband, A.J, Laskow, D.A, Mann, R.A
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 01.11.2010
Elsevier
Subjects
Acute Disease
Adolescent
Biological and medical sciences
Bone Marrow Examination
Drug Therapy, Combination
Fatal Outcome
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft vs Host Disease - diagnosis
Graft vs Host Disease - drug therapy
Graft vs Host Disease - etiology
Humans
Immunosuppressive Agents - therapeutic use
Karyotyping
Kidney Transplantation - adverse effects
Male
Medical sciences
Middle Aged
Pancreas Transplantation - adverse effects
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue, organ and graft immunology
Treatment Outcome
Human
Immunopathology
Graft versus host disease
Acute
Concurrent
Transplantation
Homotransplantation
Kidney
Case study
Medicine
Treatment
Urinary system
Combined surgery
Graft
Pancreas
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Summary:Abstract Whereas neutropenia is common after solid-organ transplantation, graft-vs-host disease is unusual, especially after simultaneous pancreas-kidney transplantation. Most cases reported in the literature give few details of treatment approach, and all were fatal. A 45-year-old man with diabetes underwent simultaneous pancreas-kidney transplantation at our center, with organs from a female donor. Two weeks postoperatively, he was readmitted with fever, malaise, and neutropenia. A bone marrow biopsy specimen demonstrated that two-thirds of the lymphocytes were of female karyotype. Graft-vs-host disease was diagnosed. Aggressive immunosuppression therapy was administered; however, the patient died. To our knowledge, this is the first case report with specific details of a treatment protocol and sequential short tandem repeat data.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2010.08.058