Induction of immune tolerance, the future of the Registry

Factor VIII (FVIII) inhibitors are IgG antibodies that neutralize the procoagulant activity of FVIII, rendering hemorrhages difficult to manage. There may exist a genetic predisposition with consequent imbalance of T and B cell function. Efforts at inhibitor eradication in the last 20 years have pro...

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Bibliographic Details
Published inVox sanguinis Vol. 70 Suppl 1; p. 47
Main Author Ewing, N P
Format Journal Article
LanguageEnglish
Published England 01.01.1996
Subjects
Factor VIII - adverse effects
Factor VIII - immunology
Forecasting
Hemophilia A - drug therapy
Hemophilia A - immunology
Humans
Immune Tolerance
Registries
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Summary:Factor VIII (FVIII) inhibitors are IgG antibodies that neutralize the procoagulant activity of FVIII, rendering hemorrhages difficult to manage. There may exist a genetic predisposition with consequent imbalance of T and B cell function. Efforts at inhibitor eradication in the last 20 years have produced a multitude of immune tolerance induction (IIT) protocols with variable outcome. Data derived from the International Registry indicate that inhibitor titer at outset of IIT and dose of FVIII concentrate used are important predictors of success. Future Registry activities should identify optimally standardized IIT regimens designed on the basis of patient likelihood to achieve tolerance and should provide further understanding of T and B cell interaction in the treatment process.
ISSN:0042-9007
DOI:10.1111/j.1423-0410.1996.tb01349.x