Polyelectrolyte thromboresistant affinity coatings for modification of devices contacting blood
The modification of hydrophobic polyethylene/polystyrene surfaces of medical devices with bilayer/multilayer coatings (BCs/MCs) based on polyelectrolyte complexes (PEC) of modified poly(N‐vinylpyrrolidone‐co‐maleic acid) copolymer (VPMA) with chitosan, amphiphilic chitosan, or albumin was studied. T...
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Published in | Journal of biomedical materials research. Part A Vol. 82A; no. 3; pp. 589 - 598 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.09.2007
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Subjects | |
Online Access | Get full text |
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Summary: | The modification of hydrophobic polyethylene/polystyrene surfaces of medical devices with bilayer/multilayer coatings (BCs/MCs) based on polyelectrolyte complexes (PEC) of modified poly(N‐vinylpyrrolidone‐co‐maleic acid) copolymer (VPMA) with chitosan, amphiphilic chitosan, or albumin was studied. The VPMA contained l‐Lysine as affinity ligand for plasminogen attached through α‐amino group. The surface properties and chemical composition of the surfaces investigated were analyzed, using sessile‐drop water contact angle measurements, attenuated total reflectance Fourier‐transform infrared spectroscopy (ATR‐FTIR), X‐ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). The specific adsorption of plasminogen (precursor of fibrinolytic enzyme plasmin) from its solutions and from human blood plasma on the modified surfaces was investigated. It was established that polyelectrolyte MCs are more efficient than single‐layer BCs and the affine polymer coatings without interlayer. A thrombogenicity decrease for the materials modified with BCs and MCs was shown in in vitro and ex vivo trials. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2007 |
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Bibliography: | ark:/67375/WNG-KBWMT291-8 RFBR - No. RFBR 04-03-32473 istex:0C315FCA2731E69B089BD1052849FB230AF6717B INTAS - No. INTAS 06-109-4966 ArticleID:JBM31178 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 1549-3296 1552-4965 |
DOI: | 10.1002/jbm.a.31178 |