Family association studies of markers on chromosome 2q and Type 1 diabetes in subjects from South India

• Published in: Diabetes/metabolism research and reviews Vol. 16; no. 4; pp. 276 - 280
• Main Authors: Ogunkolade, William B., Ramachandran, Ambady, McDermott, Michael F., Kumarajeewa, Thisum R., Curtis, David, Snehalatha, Chamakta, Mohan, Viswanathan, Cassell, Paul G., Eskdale, Joyce, Gallagher, Grant, Hitman, Graham A.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.07.2000; Wiley
• Subjects: Adolescent; Adult; Age of Onset; Biological and medical sciences; chromosome 2; Chromosome Mapping; Chromosomes, Human, Pair 2; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Genetic Markers; genetic susceptibility; Humans; India; Interleukin-1 - genetics; Linkage Disequilibrium; Male; Medical sciences; Multigene Family; South Indian; Tropical medicine; Type 1 diabetes; Asia; India; Endocrinopathy; Human; Immunopathology; Linkage; Cytokine; Autoimmune disease; Chromosome 2; Genetic determinism; Gene; Etiology; Interleukin 1; Insulin dependent diabetes; Biological receptor
• ISSN: 1520-7552; 1520-7560
• DOI: 10.1002/1520-7560(200007/08)16:4<276::AID-DMRR128>3.0.CO;2-W

Background Several Type 1 diabetes susceptibility loci have been located to chromosome 2q12–21. However, results have not always been consistent and this may reflect study design and the population analysed. We have used a family‐based design to look for an association between Type 1 diabetes and markers located to 2q12–21. Methods Ninety‐one South Indian families consisting of subjects with Type 1 diabetes and their parents were genotyped for eight polymorphic markers localised to 2q12–21, which includes the interleukin‐1 gene cluster. Radiation hybrid mapping was used to localise the map position of D2S308 and D2S363 on 2q12–21. The extended transmission disequilibrium test was used for statistical analysis. Results No associations were found between Type 1 diabetes and markers located in and around the interleukin‐1 gene cluster or the interleukin‐1 Type 1 receptor. In contrast, a suggestive association was found between Type 1 diabetes and two closely‐linked markers telomeric of the interleukin‐1 gene cluster (D2S308 and D2S363, separated by 3.3 cR) (p=0.004 and p=0.002, respectively). Conclusion This preliminary study suggests that a locus close to D2S308 and D2S363 is involved in the aetiology of Type 1 diabetes in the South Indian population. Copyright © 2000 John Wiley & Sons, Ltd.