All-in-One Target-Cell-Specific Magnetic Nanoparticles for Simultaneous Molecular Imaging and siRNA Delivery

Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD-peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance)...

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Published inAngewandte Chemie (International ed.) Vol. 48; no. 23; pp. 4174 - 4179
Main Authors Lee, Jae-Hyun, Lee, Kyuri, Moon, Seung Ho, Lee, Yuhan, Park, Tae Gwan, Cheon, Jinwoo
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 25.05.2009
WILEY‐VCH Verlag
Subjects
Cell Line, Tumor
drug delivery
Ferric Compounds - chemistry
Fluorescent Dyes - chemistry
Gene Knockdown Techniques
Gene Silencing
Humans
magnetic nanoparticles
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetics
multimodal imaging
Nanoparticles - chemistry
Neoplasms - genetics
Oligopeptides - chemistry
RNA, Small Interfering - chemistry
RNA, Small Interfering - genetics
siRNA
Spectrometry, Fluorescence - methods
Transfection
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Summary:Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD-peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.
Bibliography:http://dx.doi.org/10.1002/anie.200805998
These authors contributed equally.
This research was supported by the National Research Laboratory Program (M10600000255 for J.C. and N01080127 for T.G.P.), AFOSR (FA4869‐08‐1‐4046), NCI Center for Cancer Nanotechnology Excellence (CCNE), NCRC (R15‐2004‐024‐00000‐0), the Ministry of Health, Welfare, and Family Affairs (N04080181), the Korea Research Council of Fundamental Science & Technology, and the second‐stage BK21 project for chemistry at Yonsei University. siRNA=small interfering RNA.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200805998