Pancytopenia in allogeneic marrow transplant recipients: role of cytomegalovirus

We describe the clinical course of three cytomegalovirus-antibody-positive allogeneic marrow graft recipients who developed progressive pancytopenia during the third month post-transplant. Bone marrow biopsy cores were hypocellular without evidence of disease recurrence. Haemopoietic progenitor assa...

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Bibliographic Details
Published inBritish journal of haematology Vol. 87; no. 2; p. 357
Main Authors Bilgrami, S, Almeida, G D, Quinn, J J, Tuck, D, Bergstrom, S, Dainiak, N, Poliquin, C, Ascensao, J L
Format Journal Article
LanguageEnglish
Published England 01.06.1994
Subjects
Adult
Bone Marrow - microbiology
Bone Marrow Transplantation
Cytomegalovirus - isolation & purification
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - therapy
DNA, Viral - analysis
Female
Ganciclovir - therapeutic use
Humans
Immunocompromised Host
Immunoglobulins, Intravenous - therapeutic use
Middle Aged
Opportunistic Infections - complications
Pancytopenia - microbiology
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Summary:We describe the clinical course of three cytomegalovirus-antibody-positive allogeneic marrow graft recipients who developed progressive pancytopenia during the third month post-transplant. Bone marrow biopsy cores were hypocellular without evidence of disease recurrence. Haemopoietic progenitor assays demonstrated a decrease of all assayable progenitors. Cytomegalovirus was identified from the blood and urine of all three patients. However, none of the patients developed other manifestations of cytomegalovirus infection such as pneumonitis, hepatitis and enteritis. The therapeutic use of ganciclovir and intravenous immunoglobulins resulted in prompt resolution of both viraemia and viruria in all three patients, and of pancytopenia in two patients.
ISSN:0007-1048
DOI:10.1111/j.1365-2141.1994.tb04922.x