The C46T polymorphism of the coagulation factor XII gene and idiopathic recurrent miscarriage

Thrombophilia has been described to be involved in the pathogenesis of idiopathic recurrent miscarriage (IRM). We investigated the association between IRM and a C→T polymorphism at nucleotide 46 in the 5′‐untranslated region of the coagulation factor XII (FXII) gene. Two hundred and twelve women wit...

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Published inBJOG : an international journal of obstetrics and gynaecology Vol. 112; no. 10; pp. 1434 - 1436
Main Authors Walch, Katharina, Riener, Eva‐Katrin, Tempfer, Clemens B., Endler, Georg, Huber, Johannes C., Unfried, Gertrud
Format Journal Article
LanguageEnglish
Published Oxford, UK and Malden, USA Blackwell Science Ltd 01.10.2005
Blackwell
Subjects
Abortion, Habitual - genetics
Adult
Biological and medical sciences
Diseases of mother, fetus and pregnancy
Factor XII - genetics
Female
Gene Frequency
Genotype
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Parity
Polymorphism, Genetic - genetics
Pregnancy
Pregnancy. Fetus. Placenta
Habitual abortion
Genetic variability
Pregnancy disorders
Gene
Gynecology
Idiopathic
Genotype
Genetics
Factor XII
Coagulation factor
Obstetrics
Polymorphism
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Summary:Thrombophilia has been described to be involved in the pathogenesis of idiopathic recurrent miscarriage (IRM). We investigated the association between IRM and a C→T polymorphism at nucleotide 46 in the 5′‐untranslated region of the coagulation factor XII (FXII) gene. Two hundred and twelve women with a history of IRM and 149 healthy controls were tested by a mutagenically separated polymerase chain reaction assay (MS PCR). Allele and genotype frequencies were not significantly different between the study and the control groups. Our data suggest that the FXII gene is not a candidate gene for this condition.
ISSN:1470-0328
1471-0528
DOI:10.1111/j.1471-0528.2005.00686.x