Long-term effects of the menopause and sex hormones on skin thickness

Skin collagen content and skin thickness in a group of postmenopausal women who had been treated with sex hormone implants were compared with those in an untreated group of similar women. Both skin collagen content and thickness were found to be significantly greater in the treated than in the untre...

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Bibliographic Details
Published inBritish journal of obstetrics and gynaecology Vol. 92; no. 3; p. 256
Main Authors Brincat, M, Moniz, C J, Studd, J W, Darby, A, Magos, A, Emburey, G, Versi, E
Format Journal Article
LanguageEnglish
Published England 01.03.1985
Subjects
Collagen - analysis
Estradiol - pharmacology
Female
Gonadal Steroid Hormones - pharmacology
Humans
Menopause
Middle Aged
Skin - analysis
Skin - drug effects
Skinfold Thickness
Testosterone - pharmacology
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Summary:Skin collagen content and skin thickness in a group of postmenopausal women who had been treated with sex hormone implants were compared with those in an untreated group of similar women. Both skin collagen content and thickness were found to be significantly greater in the treated than in the untreated group. In the untreated women skin collagen content declined in relation to menopausal age but not to chronological age. No correlation was found with menopausal age, chronological age or duration of therapy in the treated group. These data suggest that skin collagen is influenced by the sex hormone status and declines after the menopause, contributing to the increase in urinary hydroxyproline excretion that has been reported to occur at this time.
ISSN:0306-5456
DOI:10.1111/j.1471-0528.1985.tb01091.x