Hyperimmunoglobulinemia D and periodic fever syndrome in children. Review on therapy with biological drugs and case report
Hyperimmunoglobulinemia D syndrome (HIDS) is a rare, autosomal recessively inherited autoinflammatory disease caused by mutations in the mevalonate kinase gene. HIDS usually starts in infancy with recurrent fever episodes lasting 3–7 days and recurring every 4–6 weeks, with only partial symptom decr...
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Published in | Acta Paediatrica Vol. 100; no. 1; pp. 21 - 25 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.01.2011
Blackwell Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Hyperimmunoglobulinemia D syndrome (HIDS) is a rare, autosomal recessively inherited autoinflammatory disease caused by mutations in the mevalonate kinase gene. HIDS usually starts in infancy with recurrent fever episodes lasting 3–7 days and recurring every 4–6 weeks, with only partial symptom decrease in adulthood. Fever is typically accompanied by abdominal pain, vomiting, diarrhoea and cervical lymphadenopathy, and sometimes by skin and joint symptoms. Blood leukocytes and serum C‐reactive protein are elevated during the episode, and in addition, high levels of interleukine‐1 (IL‐1), IL‐6 and tumour necrosis factor (TNF) and respective soluble receptors have been measured. Instead, serum immunoglobulin D (IgD) is usually normal until 3 years of age. Currently, there is no established treatment for HIDS. Thus far, four children have been successfully treated with etanercep, TNF‐alpha inhibitor, and three children with anakinra, IL‐1 receptor antagonist.
Conclusion: This review summarizes currently available data on the use biological medicines for HIDS in children. A Finnish 1.5‐year‐old patient with disease onset at 6 months of age, treated successfully with anakinra, is presented. |
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Bibliography: | istex:EE0B5E55A286AEF1043A921B778A8535491FF2C6 ark:/67375/WNG-ZKT837CQ-2 ArticleID:APA1974 ObjectType-Case Study-3 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Review-1 ObjectType-Feature-5 ObjectType-Report-2 ObjectType-Article-4 |
ISSN: | 0803-5253 1651-2227 |
DOI: | 10.1111/j.1651-2227.2010.01974.x |