Linking Pluripotency Reprogramming and Cancer

• Published in: Stem cells translational medicine Vol. 6; no. 2; pp. 335 - 339
• Main Authors: Iglesias, Juan Manuel, Gumuzio, Juan, Martin, Angel G.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.02.2017; John Wiley and Sons Inc
• Subjects: Animals; Breast cancer; Cancer therapies; Cell Movement; Cell Plasticity; Cell Proliferation; Cellular Reprogramming; Cellular Reprogramming Techniques; Cloning; DNA methylation; Drug development; Drugs; Epigenetics; Fibroblasts; Gene Expression Regulation, Neoplastic; Genes; Humans; Induced Pluripotent Stem Cells - metabolism; Induced Pluripotent Stem Cells - pathology; Metabolism; Metastasis; Molecular modelling; Motility; Neoplasm Invasiveness; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Phenotype; Phenotypes; Plasticity; Pluripotency; Signal Transduction; SOXB1 Transcription Factors - genetics; SOXB1 Transcription Factors - metabolism; Stem cells; Tumor cells; Tumorigenesis; Tumors
• ISSN: 2157-6564; 2157-6580
• DOI: 10.5966/sctm.2015-0225

Summary Tumor development and the generation of induced pluripotent stem cells are highly comparable processes with striking similarities. Cellular plasticity is inherent to tumor evolution, rendering cells that acquire a stem cell‐like phenotype, for which Sox2 activation has proved instrumental for the plastic acquisition of stemness properties in tumor cells. Understanding the molecular mechanisms underlying both events might uncover novel approaches for the development of anticancer therapeutics and constitute model systems for understanding tumor generation and ensuring the biosafety of cell‐based therapies. Stem Cells Translational Medicine 2017;6:335–339