Meta-Analysis Reveals The Association Between Male Occupational Exposure to Solvents and Impairment of Semen Parameters

Solvent exposure is among the most common occupational exposures to chemical toxicants; data about the impact of such exposure on semen parameters are contradictory. We conducted the first meta-analysis to evaluate the risk of alteration in semen parameters related to occupational exposure to solven...

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Bibliographic Details
Published inJournal of occupational and environmental medicine
Main Authors Ianos, Oana, Sari-Minodier, Irène, Villes, Virginie, Lehucher-Michel, Marie-Pascale, Loundou, Anderson, Perrin, Jeanne
Format Journal Article
LanguageEnglish
Published United States 01.10.2018
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Summary:Solvent exposure is among the most common occupational exposures to chemical toxicants; data about the impact of such exposure on semen parameters are contradictory. We conducted the first meta-analysis to evaluate the risk of alteration in semen parameters related to occupational exposure to solvents. From the PubMed database, we selected studies analysing the semen of subjects occupationally exposed to solvents, compared to unexposed controls. The meta-analysis was performed on the various semen parameters analysed in both populations. Seven studies were included in the study. The meta-analysis revealed a significant decrease in ejaculate volume [SMD = -0.35 (-0.63; -0.07)] and sperm concentration [SMD = -0.36 (-0.64, -0.08)] in workers exposed to solvents compared to in unexposed controls. Our results highlight the importance of preventing reprotoxic risks to male fertility in the workplace.
ISSN:1536-5948
DOI:10.1097/JOM.0000000000001422