Reassortant infectious bursal disease virus isolated in China

• Published in: Virus research Vol. 131; no. 2; pp. 279 - 282
• Main Authors: Wei, Yongwei, Yu, Xuping, Zheng, Jiangtao, Chu, Wuying, Xu, Hong, Yu, Xiameng, Yu, Lian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2008
• Subjects: Animals; Avibirnavirus; Bird Diseases - virology; Birnaviridae Infections - veterinary; Birnaviridae Infections - virology; Chickens; China; Emergence; Evolution; Genome, Viral; IBDV; Infectious bursal disease virus; Infectious bursal disease virus - genetics; Infectious bursal disease virus - isolation & purification; Infectious bursal disease virus - pathogenicity; Molecular Sequence Data; Phylogeny; Reassortant; Reassortant Viruses - genetics; Reassortant Viruses - isolation & purification; RNA, Viral - genetics; Sequence Analysis, DNA; Virulence; China; IBDV; Evolution; Virulence; Emergence; Reassortant
• ISSN: 0168-1702; 1872-7492
• DOI: 10.1016/j.virusres.2007.08.013

Infectious bursal disease virus (IBDV) is a bi-segmented, double-stranded RNA virus which belongs to the genus Avibirnavirus of the family Birnavirideae. In this study, we determined the complete nucleotide sequences of a reassortment IBDV strain TL2004 with segments A and B derived from attenuated and very virulent strains of IBDV. This strain is pathogenic to SPF-embryonated eggs and chickens, although it is not as virulent as very virulent strain. Genomic sequence in GenBank analysis showed that both types of natural genetic reassortment of infectious bursal disease virus emerged in China. Our findings, which strongly suggest genetic exchange between attenuated and very virulent strains of IBDV, emphasizes the risk of generating uncontrolled chimeric viruses by using live attenuated vaccines.