Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway
The Salvador–Warts–Hippo (SWH) pathway is a key controller of tissue growth in both flies and mammals, and deregulation of pathway activity contributes to tumour formation. The SWH pathway regulates cell growth, proliferation and apoptosis by restricting activity of the Yorkie transcriptional co-act...
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Published in | Cell death and differentiation Vol. 18; no. 8; pp. 1346 - 1355 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.08.2011
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | The Salvador–Warts–Hippo (SWH) pathway is a key controller of tissue growth in both flies and mammals, and deregulation of pathway activity contributes to tumour formation. The SWH pathway regulates cell growth, proliferation and apoptosis by restricting activity of the Yorkie transcriptional co-activator protein. The proteins that function together with Yorkie to drive transcription and tissue growth are beginning to be revealed and include the Scalloped (Sd), Teashirt (Tsh) and Homothorax (Hth) transcription factors. In this study, we define Wbp2 as a promoter of Yorkie-dependent growth of
Drosophila melanogaster
tissues. Mammalian WBP2 was previously identified as a protein that interacts with the mammalian Yorkie homologue, Yes-associated protein. WBP2 has been shown to enhance steroid hormone-dependent transcription in cultured cells but its
in vivo
function has remained obscure. We show that
D. melanogaster
Wbp2 interacts with Yorkie in a WW domain- and PY motif-dependent manner and that Wbp2 can enhance Yorkie's transcriptional co-activator properties.
In vivo
, Wbp2 is required for growth of the
D. melanogaster
wing, and reduction of Wbp2 expression suppresses overgrowth of tissues that lack the
warts
growth-suppressive gene. Collectively, these studies define an important role for Wbp2 as a downstream component of the SWH tissue growth-control pathway. |
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Bibliography: | These authors contributed equally to this work. |
ISSN: | 1350-9047 1476-5403 |
DOI: | 10.1038/cdd.2011.6 |