Validation of the Addenbrooke's Cognitive Examination III in Frontotemporal Dementia and Alzheimer's Disease

• Published in: Dementia and geriatric cognitive disorders Vol. 36; no. 3-4; pp. 242 - 250
• Main Authors: Hsieh, Sharpley, Schubert, Samantha, Hoon, Christopher, Mioshi, Eneida, Hodges, John R.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.01.2013; S. Karger AG
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer Disease - psychology; Attention - physiology; Biological and medical sciences; Cardiac dysrhythmias; Cardiology. Vascular system; Cognition - physiology; Data Interpretation, Statistical; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia; Female; Frontotemporal Dementia - diagnosis; Frontotemporal Dementia - psychology; Heart; Humans; Language; Male; Medical sciences; Memory - physiology; Middle Aged; Neurology; Neuropsychological Tests; Original Research Article; Reproducibility of Results; Space Perception - physiology; Verbal Learning; Visual Perception - physiology; Wechsler Scales; Frontotemporal dementia; Neuropsychological tests; Alzheimer's disease; Cognitive screening test; Nervous system diseases; Cognitive disorder; Alzheimer disease; Central nervous system disease; Neuropsychological test; Degenerative disease; Screening test; Cerebral disorder
• ISSN: 1420-8008; 1421-9824; 1421-9824
• DOI: 10.1159/000351671

Background/Aims: The aims of this study were to validate the newly developed version of the Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia. Methods: A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and Alzheimer's disease, AD, n = 28) and 25 controls were included in the study. Results: ACE-III cognitive domains correlated significantly with standardised neuropsychological tests used in the assessment of attention, language, verbal memory and visuospatial function. The ACE-III also compared very favourably with its predecessor, the ACE-R, with similar levels of sensitivity and specificity. Conclusion: The results of this study provide objective validation of the ACE-III as a screening tool for cognitive deficits in FTD and AD.