Interleukin-6 and selected plasma proteins in healthy persons of different ages

• Published in: Neurobiology of aging Vol. 15; no. 6; pp. 771 - 772
• Main Authors: Hager, Klaus, Machein, Uwe, Krieger, Stephan, Platt, Dieter, Seefried, Gerhard, Bauer, Joachim
• Format: Journal Article
• Language: English
• Published: London Elsevier Inc 01.11.1994; Elsevier Science
• Subjects: Acute phase proteins; Acute-Phase Proteins - metabolism; Adult; Age; Aged; Aged, 80 and over; Aging - blood; Biological and medical sciences; Development. Metamorphosis. Moult. Ageing; Fundamental and applied biological sciences. Psychology; Humans; Interleukin-6; Interleukin-6 - blood; Middle Aged; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Age; Acute phase proteins; Interleukin-6; Human; Interleukin 6; Acute phase protein; Senescence; Cytokine
• ISSN: 0197-4580; 1558-1497
• DOI: 10.1016/0197-4580(94)90066-3

In the present study, interleukin-6(IL-6) and several acute phase proteins were measured in healthy participants (23–87 years of age). A linear correlation between IL-6 and age was established with an increase of 0.016 pg/ml(00.004) per year of life. Whereas CRP remained below 0.5 mg/dl in all participants, an increase with age for fibrinogen and an inverse relation for albumin as well as transferrin were obtained. However, the increase of IL-6 did not correlate with any of these changes. IL-6 associated diseases may therefore occur more often with advancing age, but in healthy participants IL-6 does not explain the changing plasma protein pattern resembling that of an acute phase reaction.