Advances in the preparation and synthesis of heparin and related products
[Display omitted] •Metabolic engineering of heparosan, heparin and heparan sulfate•Chemical and chemoenzymatic synthesis of low molecular weight heparins•Development of new heparin products Heparin is a naturally occurring glycosaminoglycan from livestock, principally porcine intestine, and is clini...
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Published in | Drug discovery today Vol. 25; no. 12; pp. 2095 - 2109 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.12.2020
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Subjects | |
Online Access | Get full text |
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Summary: | [Display omitted]
•Metabolic engineering of heparosan, heparin and heparan sulfate•Chemical and chemoenzymatic synthesis of low molecular weight heparins•Development of new heparin products
Heparin is a naturally occurring glycosaminoglycan from livestock, principally porcine intestine, and is clinically used as an anticoagulant drug. A limitation to heparin production is that it depends on a single animal species and potential problems have been associated with animal-derived heparin. The contamination crisis in 2008 led to a search for new animal sources and the investigation of non-animal sources of heparin. Over the past 5 years, new animal sources, chemical, and chemoenzymatic methods have been introduced to prepare heparin-based drugs. In this review, we describe advances in the preparation and synthesis of heparin and related products.
We review recent advances in the field of preparation and synthesis of indispensable anticoagulant drugs, heparin, and related products. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1359-6446 1878-5832 |
DOI: | 10.1016/j.drudis.2020.09.011 |