Roles of multiple accessory molecules in T-cell activation

Accessory molecules expressed on T cells can mediate adhesion between T cells and other cells, or the extracellular matrix. The same T-cell accessory molecules participate in a dialogue with their ligands (counter-receptors) on the antigen-presenting cells, and elicit signals that determine the spec...

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Bibliographic Details
Published inCurrent opinion in immunology Vol. 3; no. 3; pp. 294 - 303
Main Authors van Seventer, Gijs A., Shimizu, Yoji, Shaw, Stephen
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.1991
Subjects
Animals
Antigen-Presenting Cells - immunology
Cell Adhesion - immunology
Cell Adhesion Molecules - immunology
Cell Communication - immunology
Cell Differentiation - immunology
Humans
Lymphocyte Activation
Signal Transduction - immunology
T-Lymphocytes - cytology
T-Lymphocytes - immunology
LN
TCR
IL
ICAM
LFA
FN
[Ca 2+] i
PKC
VLA
TNF
ECM
mAb
ELAM
APC
Th
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Summary:Accessory molecules expressed on T cells can mediate adhesion between T cells and other cells, or the extracellular matrix. The same T-cell accessory molecules participate in a dialogue with their ligands (counter-receptors) on the antigen-presenting cells, and elicit signals that determine the specifics of activation and subsequent differentiation of the T cells and antigen-presenting cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
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ISSN:0952-7915
1879-0372
DOI:10.1016/0952-7915(91)90027-X