Sequential use of mifepristone and misoprostol in treatment of early pregnancy failure appears more effective than misoprostol alone: a retrospective study

• Published in: European journal of obstetrics & gynecology and reproductive biology Vol. 183; pp. 16 - 19
• Main Authors: van den Berg, Joyce, van den Bent, Johan M, Snijders, Marcus P, de Heus, Roel, Coppus, Sjors F, Vandenbussche, Frank P
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.12.2014
• Subjects: Abortifacient Agents, Nonsteroidal - administration & dosage; Abortifacient Agents, Nonsteroidal - therapeutic use; Abortifacient Agents, Steroidal - administration & dosage; Abortifacient Agents, Steroidal - therapeutic use; Abortion, Spontaneous - drug therapy; Administration, Intravaginal; Administration, Oral; Adult; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Early pregnancy failure; Female; Humans; Mifepristone; Mifepristone - administration & dosage; Mifepristone - therapeutic use; Misoprostol; Misoprostol - administration & dosage; Misoprostol - therapeutic use; Obstetrics and Gynecology; Pregnancy; Retrospective Studies; Treatment Outcome; Mifepristone; Early pregnancy failure; Misoprostol
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/j.ejogrb.2014.10.010

Abstract Objective Is treatment of early pregnancy failure (EPF) with sequential use of mifepristone and misoprostol more effective than treatment with misoprostol alone? Study design In a retrospective cohort study at the Department of Obstetrics and Gynaecology of the Radboud University Medical Centre, 301 women with early pregnancy failure receiving medical treatment between January 2008 and March 2013 were included. Of these, 199 women were pre-treated with 200 mg mifepristone (orally) followed by 2 consecutive doses of 800 mcg misoprostol (vaginally) and 102 women were treated with 2 consecutive doses of 800 mcg misoprostol (vaginally) alone. Results Complete expulsion was achieved in 66.8% of the women treated with a sequential combination of mifepristone and misoprostol versus 54.9% of the women treated with misoprostol alone. The difference in rates of complete expulsion was 11.9% ( P < 0.05; 95% CI 0.3–23.6%). Conclusions Medical treatment of early pregnancy failure with a sequential combination of mifepristone and misoprostol was more effective than treatment with misoprostol alone. Our findings will have to be confirmed by a large prospective multicentre double blinded-randomized trial.