Safety and effectiveness of the Genous™ endothelial progenitor cell-capture stent in the first year following ST-elevation acute myocardial infarction: A single center experience and review of the literature

• Published in: Cardiovascular revascularization medicine Vol. 14; no. 6; pp. 338 - 342
• Main Authors: Pereira-da-Silva, Tiago, Bernardes, Luís, Cacela, Duarte, Fiarresga, António, Sousa, Lídia, Patrício, Lino, Ferreira, Rui Cruz
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2013
• Subjects: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary - methods; Cardiovascular; Coronary Angiography - methods; Electrocardiography - methods; Endothelial Cells - cytology; Endothelial progenitor cell; Female; Humans; Male; Middle Aged; Myocardial Infarction - surgery; Percutaneous coronary intervention; Review Literature as Topic; ST-elevation acute myocardial infarction; Stem Cells - cytology; Stem Cells - metabolism; Stent; Stents - adverse effects; Thrombosis - surgery; Treatment Outcome; thrombolysis in myocardial infarction; major adverse cardiac event; target lesion revascularization; Endothelial progenitor cell; GS; ST-elevation acute myocardial infarction; Stent; dual antiplatelet therapy; TVR; percutaneous coronary intervention; MACE; TIMI; PCI; STEMI; target vessel revascularization; Genous™ stent; TLR; DAPT; Percutaneous coronary intervention
• ISSN: 1553-8389; 1878-0938
• DOI: 10.1016/j.carrev.2013.09.004

Abstract Purpose The Genous™ stent (GS) is designed to accelerate endothelization, which is potentially useful in the pro-thrombotic environment of ST-elevation acute myocardial infarction (STEMI). We aimed to evaluate the safety and effectiveness of the GS in the first year following primary percutaneous coronary intervention (PCI) and to compare our results with the few previously published studies. Methods and Materials All patients admitted to a single center due to STEMI that underwent primary PCI using exclusively GS, between May 2006 and January 2012, were enrolled. The primary study endpoints were major adverse cardiac events (MACEs), defined as the composite of cardiac death, acute myocardial infarction and target vessel revascularization, at one and 12 months. Results In the cohort of 109 patients (73.4% male, 59 ± 12 years), 24.8% were diabetic. PCI was performed in 116 lesions with angiographic success in 99.1%, using 148 GS with median diameter of 3.00 mm (2.50–4.00) and median length of 15 mm (9–33). Cumulative MACEs were 2.8% at one month and 6.4% at 12 months. Three stent thromboses (2.8%), all subacute, and one stent restenosis (0.9%) occurred. These accounted for the four target vessel revascularizations (3.7%). At 12 months, 33.9% of patients were not on dual antiplatelet therapy. Conclusions GS was safe and effective in the first year following primary PCI in STEMI, with an apparently safer profile comparing with the previously published data. Summary We report the safety and effectiveness of the Genous™ stent (GS) in the first year following primary percutaneous coronary intervention in ST-elevation acute myocardial infarction. A comprehensive review of the few studies that have been published on this subject was included and some suggest a less safe profile of the GS. Our results and the critical review included may add information and reinforce the safety and effectiveness of the GS in ST-elevation in acute myocardial infarction.