Efficacy of HPA Lanolin® in treatment of lip alterations related to chemotherapy

• Published in: Journal of applied oral science Vol. 21; no. 2; pp. 163 - 166
• Main Authors: Santos, Paulo Sérgio da Silva, Tinôco-Araújo, José Endrigo, Souza, Lucas Monteiro de Vasconcelos Alves de, Ferreira, Rafael, Ikoma, Maura Rosane Valério, Razera, Ana Paula Ribeiro, Santos, Márcia Mirolde Magno de Carvalho
• Format: Journal Article
• Language: English
• Published: Brazil Faculdade de Odontologia de Bauru da Universidade de São Paulo 01.04.2013; Faculdade De Odontologia De Bauru - USP; University of São Paulo
• Subjects: Adolescent; Adult; Antineoplastic Agents - adverse effects; Chemotherapy; Cosmetics - therapeutic use; Dehydration - prevention & control; DENTISTRY, ORAL SURGERY & MEDICINE; Female; Humans; Lanolin; Lanolin - therapeutic use; Lip; Lip - drug effects; Male; Mucositis - prevention & control; Neoplasms - drug therapy; Original; Pain - prevention & control; Pain Measurement; Patient care; Prospective Studies; Statistics, Nonparametric; Time Factors; Treatment Outcome; Young Adult; Chemotherapy; Lip; Lanolin; Patient care
• ISSN: 1678-7757; 1678-7765; 1678-7765; 1678-7757
• DOI: 10.1590/1678-7757201302308

The side effects of chemotherapy on the lips may cause esthetic and functional impact and increase the risk of infection. HPA Lanolin® is an option for supportive therapy because it has anti-inflammatory, antimicrobial and moisturizing properties. To evaluate the efficacy of this product in the prevention of lip alterations in a population of patients undergoing chemotherapy. Patients undergoing chemotherapy (n = 57) were examined and distributed into two groups: study (used HPA Lanolin®) and control (without supportive therapy on the lips). We evaluated the patients two weeks after chemotherapy, registering oral alterations, symptoms of pain, discomfort, limitation of mouth opening and dehydration, classified according to a visual analogue scale. Patients who used HPA Lanolin® had lower dehydration and experienced improvement of lip dryness (p<0.001). The main symptoms were dehydration, discomfort, limitation of mouth opening, pain. The main clinical signs were dry lips, mucositis, cheilitis, hematoma, swelling and cracking. We found no difference concerning the variables of pain, discomfort, and limitation of mouth opening between the study and control group. We suggest that HPA Lanolin® is effective in reducing the symptoms of dehydration and the signs of lip dryness resulting from toxicity of chemotherapy, proving to be an interesting alternative supportive therapy for cancer patients.