Outside In: Inversion of Cell Polarity Controls Epithelial Lumen Formation

Establishment of cell polarity is important for epithelial lumen formation, and the molecular mechanisms directing this process are only partially understood. In this issue of Developmental Cell, Bryant et al. (2014) show that disassembly, membrane translocation, and reassembly of podocalyxin comple...

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Bibliographic Details
Published inDevelopmental cell Vol. 31; no. 2; pp. 140 - 142
Main Authors Davis, George E., Cleaver, Ondine B.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 27.10.2014
Subjects
Animals
Cell Polarity - physiology
Epithelial Cells - cytology
Epithelial Cells - metabolism
Humans
Morphogenesis
Organogenesis
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Summary:Establishment of cell polarity is important for epithelial lumen formation, and the molecular mechanisms directing this process are only partially understood. In this issue of Developmental Cell, Bryant et al. (2014) show that disassembly, membrane translocation, and reassembly of podocalyxin complexes controls epithelial cell polarization and lumen formation in 3D matrices.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2014.10.011