The Many Roles of Lysophospholipid Mediators and Japanese Contributions to This Field

Lysophospholipids are phospholipids with only one fatty acid. During the past two decades, it has become apparent that lysophospholipids are not merely degradation products but have various physiological and pathological functions in vivo via G protein-coupled receptor (GPCR)-type receptors. These i...

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Published inBiological & pharmaceutical bulletin Vol. 45; no. 8; pp. 1008 - 1021
Main Authors Takagi, Yugo, Nishikado, Shun, Omi, Jumpei, Aoki, Junken
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.08.2022
Japan Science and Technology Agency
Subjects
Degradation products
G protein-coupled receptor
G protein-coupled receptors
Lysophosphatidic acid
lysophosphatidylinositol
lysophosphatidylserine
lysophospholipid mediator
Phospholipids
Protein transport
Sphingosine 1-phosphate
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Summary:Lysophospholipids are phospholipids with only one fatty acid. During the past two decades, it has become apparent that lysophospholipids are not merely degradation products but have various physiological and pathological functions in vivo via G protein-coupled receptor (GPCR)-type receptors. These include lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), lysophosphatidylinositol/lysophosphatidylglucose (LPI/LPtdGlc), and lysophosphatidylserine (LysoPS). This review focuses on identifying the functions of the receptors, enzymes, transporters, and carrier proteins required for these four lysophospholipids to function as lipid mediators. We also note that many of advances in this field have been made by Japanese pharmaceutical scientists.
Bibliography:ObjectType-Article-2
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ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b22-00304