Severe Acute Respiratory Syndrome Coronavirus 2 Attachment Receptor Angiotensin-Converting Enzyme 2 Is Decreased in Crohn’s Disease and Regulated By Microbial and Inflammatory Signaling

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 160; no. 3; pp. 925 - 928.e4
• Main Authors: Patankar, Jay Vasant, Chiriac, Mircea Teodor, Lehmann, Malte, Kühl, Anja A., Atreya, Raja, Becker, Christoph, Gonzalez-Acera, Miguel, Schmitt, Heike, Gamez-Belmonte, Reyes, Mahapatro, Mousumi, Diemand, Leonard, Hartmann, Leonie, Mascia, Fabrizio, Hracsko, Zsuzsanna, Thonn, Veronika, Schödel, Lena, Zielinska, Marta, Yu, Yuqiang, Erkert, Lena, Li, Wei, Zeitler, Melanie, Ruder, Barbara, Ganzleben, Ingo, Günther, Claudia, Voehringer, David, Zundler, Sebastian, Neurath, Markus F., Siegmund, Britta
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2021; by the AGA Institute
• Subjects: Angiotensin-Converting Enzyme 2 - genetics; Angiotensin-Converting Enzyme 2 - metabolism; Animals; Brief Communication; Case-Control Studies; Colitis, Ulcerative - enzymology; Colitis, Ulcerative - immunology; Colitis, Ulcerative - microbiology; COVID-19 - enzymology; COVID-19 - virology; Crohn Disease - enzymology; Crohn Disease - genetics; Crohn Disease - immunology; Crohn Disease - microbiology; Disease Models, Animal; Down-Regulation; Gastrointestinal Microbiome; Host-Pathogen Interactions; Humans; Ileum - enzymology; Ileum - immunology; Ileum - microbiology; Inflammation Mediators - metabolism; Mice; Mice, Knockout; Receptors, Virus - metabolism; SARS-CoV-2 - enzymology; SARS-CoV-2 - pathogenicity; Serine Endopeptidases - metabolism; Signal Transduction; STAT Transcription Factors - genetics; STAT Transcription Factors - metabolism; Toll-Like Receptors - genetics; Toll-Like Receptors - metabolism; COVID-19; IFN; ACE2; CD; SARS-CoV-2; IEC; TMPRSS2; IBD; UC
• ISSN: 0016-5085; 1528-0012
• DOI: 10.1053/j.gastro.2020.10.021