Lead/Lag directionality is not generally equivalent to causality in nonlinear systems: Comparison of phase slope index and conditional mutual information

• Published in: NeuroImage (Orlando, Fla.) Vol. 292; p. 120610
• Main Authors: Arinyo-i-Prats, Andreu, López-Madrona, Víctor J., Paluš, Milan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2024; Elsevier Limited; Elsevier
• Subjects: Animals; Brain - physiology; Causality; Computer science; Computer Simulation; Conditional mutual information; Coupling directionality; Cross-frequency coupling; EEG; Electroencephalography; Electroencephalography - methods; Entropy; Estimates; Fourier transforms; Humans; Lattice theory; Models, Neurological; Nonlinear Dynamics; Nonlinear systems; Phase slope index; Random variables; Signal Processing, Computer-Assisted; Time series; Cross-frequency coupling; Coupling directionality; Phase slope index; Nonlinear systems; EEG; Conditional mutual information
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2024.120610

Applications of causal techniques to neural time series have increased extensively over last decades, including a wide and diverse family of methods focusing on electroencephalogram (EEG) analysis. Besides connectivity inferred in defined frequency bands, there is a growing interest in the analysis of cross-frequency interactions, in particular phase and amplitude coupling and directionality. Some studies show contradicting results of coupling directionality from high frequency to low frequency signal components, in spite of generally considered modulation of a high-frequency amplitude by a low-frequency phase. We have compared two widely used methods to estimate the directionality in cross frequency coupling: conditional mutual information (CMI) and phase slope index (PSI). The latter, applied to infer cross-frequency phase–amplitude directionality from animal intracranial recordings, gives opposite results when comparing to CMI. Both metrics were tested in a numerically simulated example of unidirectionally coupled Rössler systems, which helped to find the explanation of the contradictory results: PSI correctly estimates the lead/lag relationship which, however, is not generally equivalent to causality in the sense of directionality of coupling in nonlinear systems, correctly inferred by using CMI with surrogate data testing. •Oscillations of different frequencies can be mutually coupled or one can lead another.•Leading in time might not be equivalent to driving or controlling.•Phase Slope Index indicates lead/lag relationship.•Conditional Mutual Information infers direction of coupling (causality).•In nonlinear systems, lead/lag relationship is not generally equivalent to causality.