Elevated blood lead levels in children are associated with lower erythropoietin concentrations

Eighty-six children (mean age, 34 months) were studied to determine whether elevated blood lead levels in children are associated with lower erythropoietin concentrations. The median erythropoietin concentration was 5.9 mIU/mL (range, 2.3 to 11.5 mIU/mL), and the median blood lead level was 0.87 μmo...

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Published inThe Journal of pediatrics Vol. 134; no. 1; pp. 107 - 109
Main Authors Liebelt, Erica L., Schonfeld, David J., Gallagher, Patrick
Format Journal Article
LanguageEnglish
Published New York, NY Mosby, Inc 1999
Elsevier
Mosby-Year Book, Inc
Subjects
Analysis of Variance
Anemias. Hemoglobinopathies
Biological and medical sciences
Child
Child, Preschool
Diseases of red blood cells
Enzyme Inhibitors - blood
Enzyme-Linked Immunosorbent Assay
Erythropoietin - blood
Female
Hematologic and hematopoietic diseases
Humans
Infant
Lead - blood
Male
Medical sciences
Pilot Projects
Protoporphyrins - blood
BPb
EPO
Human
Concentration factor
Erythropoietin
Pathophysiology
Anemia
Lead
Hemopathy
Poisoning
Glycoprotein hormone
Child
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Summary:Eighty-six children (mean age, 34 months) were studied to determine whether elevated blood lead levels in children are associated with lower erythropoietin concentrations. The median erythropoietin concentration was 5.9 mIU/mL (range, 2.3 to 11.5 mIU/mL), and the median blood lead level was 0.87 μmol/L (18 μg/dL; range, 2 to 84 μg/dL). Blood lead concentration was inversely and independently related to erythropoietin concentration. (J Pediatr 1999;134:107-9)
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(99)70381-1