Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito

• Published in: Molecules (Basel, Switzerland) Vol. 20; no. 11; pp. 20823 - 20831
• Main Authors: Jung, Jae-Woo, Baek, Nam-In, Hwang-Bo, Jeon, Lee, Seung-Su, Park, Ji-Hae, Seo, Kyeong-Hwa, Kwon, Jung-Hwa, Oh, Eun-Ji, Lee, Dae-Young, Chung, In-Sik, Bang, Myun-Ho
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.11.2015; MDPI
• Subjects: adonioside A; adonioside B; Adonis - chemistry; Adonis multiflora; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Biotechnology; Cancer; cardenolide; Cardenolides - chemistry; Cardenolides - isolation & purification; Cardenolides - pharmacology; Cell Line, Tumor; Cell Survival - drug effects; Chromatography; Communication; cytotoxic activity; Hep G2 Cells; Humans; Inhibitory Concentration 50; Nuclear Magnetic Resonance, Biomolecular; Phytochemicals; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; adonioside A; adonioside B; cardenolide; cytotoxic activity; Adonis multiflora
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules201119722

A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides--adonioside A (1) and adonioside B (6)--as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).