Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019

• Published in: The Journal of infectious diseases Vol. 223; no. 4; pp. 562 - 567
• Main Authors: Bedin, Anne-Sophie, Makinson, Alain, Picot, Marie-Christine, Mennechet, Frank, Malergue, Fabrice, Pisoni, Amandine, Nyiramigisha, Esperance, Montagnier, Lise, Bollore, Karine, Debiesse, Ségolène, Morquin, David, Bourgoin, Pénélope, Veyrenche, Nicolas, Renault, Constance, Foulongne, Vincent, Bret, Caroline, Bourdin, Arnaud, Le Moing, Vincent, Van de Perre, Philippe, Tuaillon, Edouard
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 24.02.2021
• Subjects: Aged; Biomarkers; Biomarkers - metabolism; Coronaviruses; COVID-19; COVID-19 - diagnosis; COVID-19 - metabolism; Diagnosis; Early Diagnosis; Female; Flow Cytometry; Humans; Male; Medical diagnosis; Middle Aged; Monocytes; Monocytes - metabolism; Monocytes - virology; Outbreaks; Patients; ROC Curve; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Sialic Acid Binding Ig-like Lectin 1 - metabolism; Thrombocytopenia; α-Interferon; COVID-19; monocytes; SARS-CoV-2; viral infections; CD169
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/jiaa724

Abstract We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (monocyte CD169 [mCD169]) in 53 adult patients admitted to the hospital during the coronavirus disease 2019 (COVID-19) outbreak for a suspicion of severe acute respiratory syndrome coronavirus 2 infection. Monocyte CD169 was strongly overexpressed in 30 of 32 (93.7%) confirmed COVID-19 cases, compared with 3 of 21 (14.3%) patients in whom the diagnosis of COVID-19 was finally ruled out. Monocyte CD169 was associated with the plasma interferon-alpha level and thrombocytopenia. Monocyte CD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.