Pulmonary function and COVID-19

• Published in: Current opinion in physiology Vol. 21; pp. 29 - 35
• Main Authors: Thomas, Max, Price, Oliver J, Hull, James H
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2021
• ISSN: 2468-8673; 2468-8673
• DOI: 10.1016/j.cophys.2021.03.005

In people recovering from COVID-19, there is concern regarding potential long-term pulmonary sequelae and associated impairment of functional capacity. Data published thus far indicate that spirometric indices appear to be generally well preserved, but that a defect in diffusing capacity (DLco) is a prevalent abnormality identified on follow-up lung function; present in 20–30% of those with mild to moderate disease and 60% in those with severe disease. Reductions in total lung capacity were commonly reported. Functional capacity is also often impaired, with data now starting to emerge detailing walk test and cardiopulmonary exercise test outcome at follow-up. In this review, we evaluate the published evidence in this area, to summarise the impact of COVID-19 infection on pulmonary function and relate this to the clinico-radiological findings and disease severity.