Alzheimer's Disease and Helicobacter pylori Infection: Inflammation from Stomach to Brain?

Despite extensive research, the origin of Alzheimer's disease (AD) remains unknown. The role of infectious pathogens has recently emerged. Epidemiological studies have shown that Helicobacter pylori infection increases the risk of developing AD. We hypothesized that H. pylori-induced gastritis...

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Published inJournal of Alzheimer's disease Vol. 73; no. 2; p. 801
Main Authors Albaret, Guillaume, Sifré, Elodie, Floch, Pauline, Laye, Sophie, Aubert, Agnès, Dubus, Pierre, Azzi-Martin, Lamia, Giese, Alban, Salles, Nathalie, Mégraud, Francis, Varon, Christine, Lehours, Philippe, Roubaud-Baudron, Claire
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2020
Subjects
Alzheimer’s disease
neuroinflammation
dementia
iba-1
Helicobacter infection
gastric inflammation
GFAP
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Abstract Despite extensive research, the origin of Alzheimer's disease (AD) remains unknown. The role of infectious pathogens has recently emerged. Epidemiological studies have shown that Helicobacter pylori infection increases the risk of developing AD. We hypothesized that H. pylori-induced gastritis may be associated with a systemic inflammation and finally neuroinflammation. C57BL/6 mice were infected with H. pylori (n = 15) or Helicobacter felis (n = 13) or left uninfected (n = 9) during 18 months. Gastritis, amyloid deposition, astroglial and microglial cell area, and systemic and brain cytokines were assessed. The infection (H. felis> H. pylori) induced a severe gastritis and an increased neuroinflammation but without brain amyloid deposition or systemic inflammation.
AbstractList Despite extensive research, the origin of Alzheimer's disease (AD) remains unknown. The role of infectious pathogens has recently emerged. Epidemiological studies have shown that Helicobacter pylori infection increases the risk of developing AD. We hypothesized that H. pylori-induced gastritis may be associated with a systemic inflammation and finally neuroinflammation. C57BL/6 mice were infected with H. pylori (n = 15) or Helicobacter felis (n = 13) or left uninfected (n = 9) during 18 months. Gastritis, amyloid deposition, astroglial and microglial cell area, and systemic and brain cytokines were assessed. The infection (H. felis> H. pylori) induced a severe gastritis and an increased neuroinflammation but without brain amyloid deposition or systemic inflammation.
Author Sifré, Elodie
Albaret, Guillaume
Varon, Christine
Lehours, Philippe
Floch, Pauline
Aubert, Agnès
Salles, Nathalie
Roubaud-Baudron, Claire
Mégraud, Francis
Laye, Sophie
Azzi-Martin, Lamia
Giese, Alban
Dubus, Pierre
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  organization: CHU Bordeaux, Service de biologie des tumeurs - tumorothèque, Bordeaux, France
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  surname: Roubaud-Baudron
  fullname: Roubaud-Baudron, Claire
  organization: CHU Bordeaux, Pôle de Gérontologie Clinique, Bordeaux, France
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Keywords Alzheimer’s disease
neuroinflammation
dementia
iba-1
Helicobacter infection
gastric inflammation
GFAP
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Title Alzheimer's Disease and Helicobacter pylori Infection: Inflammation from Stomach to Brain?
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