Alzheimer's Disease and Helicobacter pylori Infection: Inflammation from Stomach to Brain?

Despite extensive research, the origin of Alzheimer's disease (AD) remains unknown. The role of infectious pathogens has recently emerged. Epidemiological studies have shown that Helicobacter pylori infection increases the risk of developing AD. We hypothesized that H. pylori-induced gastritis...

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Bibliographic Details
Published inJournal of Alzheimer's disease Vol. 73; no. 2; p. 801
Main Authors Albaret, Guillaume, Sifré, Elodie, Floch, Pauline, Laye, Sophie, Aubert, Agnès, Dubus, Pierre, Azzi-Martin, Lamia, Giese, Alban, Salles, Nathalie, Mégraud, Francis, Varon, Christine, Lehours, Philippe, Roubaud-Baudron, Claire
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2020
Subjects
Alzheimer’s disease
neuroinflammation
dementia
iba-1
Helicobacter infection
gastric inflammation
GFAP
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Summary:Despite extensive research, the origin of Alzheimer's disease (AD) remains unknown. The role of infectious pathogens has recently emerged. Epidemiological studies have shown that Helicobacter pylori infection increases the risk of developing AD. We hypothesized that H. pylori-induced gastritis may be associated with a systemic inflammation and finally neuroinflammation. C57BL/6 mice were infected with H. pylori (n = 15) or Helicobacter felis (n = 13) or left uninfected (n = 9) during 18 months. Gastritis, amyloid deposition, astroglial and microglial cell area, and systemic and brain cytokines were assessed. The infection (H. felis> H. pylori) induced a severe gastritis and an increased neuroinflammation but without brain amyloid deposition or systemic inflammation.
ISSN:1875-8908
DOI:10.3233/JAD-190496