Multitask Gaussian Processes for Multivariate Physiological Time-Series Analysis

• Published in: IEEE transactions on biomedical engineering Vol. 62; no. 1; pp. 314 - 322
• Main Authors: Durichen, Robert, Pimentel, Marco A. F., Clifton, Lei, Schweikard, Achim, Clifton, David A.
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.01.2015; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Algorithms; Biological system modeling; Computer Simulation; Correlation; Covariance matrices; Data Interpretation, Statistical; Delay; Gaussian; Gaussian processes; Health care; Humans; Indexes; Models, Biological; Models, Statistical; Monitoring; Multivariate Analysis; Normal Distribution; Patients; Physiology; Regression; Time series; Training; Training data; Correlation analysis; multivariate data analysis; Gaussian processes
• ISSN: 0018-9294; 1558-2531
• DOI: 10.1109/TBME.2014.2351376

Gaussian process (GP) models are a flexible means of performing nonparametric Bayesian regression. However, GP models in healthcare are often only used to model a single univariate output time series, denoted as single-task GPs (STGP). Due to an increasing prevalence of sensors in healthcare settings, there is an urgent need for robust multivariate time-series tools. Here, we propose a method using multitask GPs (MTGPs) which can model multiple correlated multivariate physiological time series simultaneously. The flexible MTGP framework can learn the correlation between multiple signals even though they might be sampled at different frequencies and have training sets available for different intervals. Furthermore, prior knowledge of any relationship between the time series such as delays and temporal behavior can be easily integrated. A novel normalization is proposed to allow interpretation of the various hyperparameters used in the MTGP. We investigate MTGPs for physiological monitoring with synthetic data sets and two real-world problems from the field of patient monitoring and radiotherapy. The results are compared with standard Gaussian processes and other existing methods in the respective biomedical application areas. In both cases, we show that our framework learned the correlation between physiological time series efficiently, outperforming the existing state of the art.