Sex-related Differences in Gene Expression in Salivary Glands of BALB/c Mice

Sex-related differences exist in the structure and function of the major glands in a variety of species. Moreover, many of these variations appear to be unique to each tissue. We hypothesized that this sexual dimorphism is due, at least in part, to gland-specific differences in gene expression betwe...

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Bibliographic Details
Published inJournal of dental research Vol. 84; no. 2; pp. 160 - 165
Main Authors Treister, N.S., Richards, S.M., Lombardi, M.J., Rowley, P., Jensen, R.V., Sullivan, D.A.
Format Journal Article
LanguageEnglish
Published United States SAGE Publications 01.02.2005
SAGE PUBLICATIONS, INC
Subjects
Animals
Dentistry
Female
Gene Expression Regulation - physiology
Male
Mice
Mice, Inbred BALB C
Oligonucleotide Array Sequence Analysis
RNA, Messenger - analysis
Salivary Glands - metabolism
Salivary Proteins and Peptides - genetics
Salivary Proteins and Peptides - metabolism
Sex Characteristics
salivary glands
gene expression
sex differences
microarrays
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Summary:Sex-related differences exist in the structure and function of the major glands in a variety of species. Moreover, many of these variations appear to be unique to each tissue. We hypothesized that this sexual dimorphism is due, at least in part, to gland-specific differences in gene expression between males and females. Glands were collected from male and female BALB/c mice (n = 5/sex/experiment), and total RNA was isolated. Samples were analyzed for differentially expressed mRNAs with CodeLink microarrays, and data were evaluated by GeneSifter. Our results demonstrate that significant (P < 0.05) sex-related differences exist in the expression of numerous genes in the major salivary glands, and many of these differences were tissue-specific. These findings support our hypothesis that sex-related differences in the salivary glands are due, at least in part, to tissue-specific variations in gene expression.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-0345
1544-0591
DOI:10.1177/154405910508400210