An increase in startle response in rats administered oxytocin

Twenty-four male albino Wistar rats were allocated to four groups and given either 23.2, 11.6 or 5.8 IU OXT/kg or vehicle (0.9% saline). A significant increase in startle response was observed in the 11.6 and 5.8 IU OXT/kg groups when compared to vehicle. Our results further support the suggestion t...

Full description

Saved in:
Bibliographic Details
Published inPeptides (New York, N.Y. : 1980) Vol. 6; no. 3; pp. 567 - 568
Main Authors King, Maurice G., Brown, Richard, Kusnecov, Alex
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.01.1985
Elsevier Science
Subjects
11-Hydroxycorticosteroids - blood
acoustic startle response
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
General aspects. Hormone interactions. Hormone actions on several organ systems. Adaptive reactions
Male
Oxytocin
Oxytocin - pharmacology
Rats
Rats, Inbred Strains
Reflex, Startle - drug effects
Reflex, Startle - physiology
Startle response
Stress
Stress, Physiological - physiopathology
Vertebrates: endocrinology
Startle response
Oxytocin
Stress
Vertebrata
Mammalia
Rat
Steroid hormone
Rodentia
Peptide hormone
Behavior
Glucocorticoid
Online AccessGet full text

Cover

More Information
Summary:Twenty-four male albino Wistar rats were allocated to four groups and given either 23.2, 11.6 or 5.8 IU OXT/kg or vehicle (0.9% saline). A significant increase in startle response was observed in the 11.6 and 5.8 IU OXT/kg groups when compared to vehicle. Our results further support the suggestion that OXT is a “stress hormone” by implicating this peptide with increased emotionality/reactivity during a stressful experience.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0196-9781
1873-5169
DOI:10.1016/0196-9781(85)90122-6