Maintaining social contacts: The physiological relevance of organelle interactions

• Published in: Biochimica et biophysica acta. Molecular cell research Vol. 1867; no. 11; p. 118800
• Main Authors: Silva, Beatriz S.C., DiGiovanni, Laura, Kumar, Rechal, Carmichael, Ruth E., Kim, Peter K., Schrader, Michael
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2020; Elsevier
• Subjects: Acyl-CoA binding domain containing protein; Cell Membrane - genetics; Endosomes - genetics; FFAT motif; Golgi Apparatus - genetics; Humans; Lipid Droplets - metabolism; Lipid metabolism; Lysosomes - genetics; Membrane contact sites; Mitochondria; Mitochondria - genetics; Peroxisomes; Peroxisomes - genetics; PEX; VAP; DMT1; FFAT motif; Mitochondria; PBD; Mdm; OSBP; VLCFA; Lipid metabolism; ERMES; PTPIP51; ABCD1; STARD3; DGAT2; MIGA2; MIRO1; IMM; Membrane contact sites; ER; Num1; OMM; PI(4,5)P2; TMEM135; INF2; NPC1; ROS; MAM; TGN; PLIN5; IP3R; MFF; ORP; CRAC; DRP1; FFAT; ATF6α; PPV; VPS13; Acyl-CoA binding domain containing protein; TBC1D15; Osh; Peroxisomes; PIP; ACBD; TAG; MCS; ATP; PM
• ISSN: 0167-4889; 1879-2596
• DOI: 10.1016/j.bbamcr.2020.118800

Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate and facilitate cellular functions. The formation of close contacts, termed “membrane contact sites” (MCSs), represents an intriguing strategy for organelle interaction and coordinated interplay. Emerging research is rapidly revealing new details of MCSs. They represent ubiquitous and diverse structures, which are important for many aspects of cell physiology and homeostasis. Here, we provide a comprehensive overview of the physiological relevance of organelle contacts. We focus on mitochondria, peroxisomes, the Golgi complex and the plasma membrane, and discuss the most recent findings on their interactions with other subcellular organelles and their multiple functions, including membrane contacts with the ER, lipid droplets and the endosomal/lysosomal compartment. [Display omitted] •Membrane contact sites (MCSs) physically and functionally link organelles.•MCSs are ubiquitous, diverse and dynamic.•Mitochondria, ER, peroxisomes, Golgi and plasma membrane all form numerous MCSs.•MCSs facilitate intracellular signalling, lipid and metabolite transfer.•MCSs are important for organelle dynamics, division and inheritance.