Application of fast sensors to microscope mode spatial imaging mass spectrometry

The application of fast detectors to microscope mode spatial imaging mass spectrometry, in which the two-dimensional distributions of particular ion masses over a sample are projected onto a two-dimensional detector, allows the imaging of all mass peaks desorbed from a sample on each time-of-flight...

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Bibliographic Details
Published inJournal of instrumentation Vol. 6; no. 1; p. C01044
Main Authors Brouard, M, Johnsen, A J, Nomerotski, A, Slater, C S, Vallance, C, Yuen, W H
Format Journal Article
LanguageEnglish
Published IOP Publishing 01.01.2011
Subjects
Cameras
Charge coupled devices
Detectors
Imaging
Instrumentation
Mass spectrometry
Microscopes
Two dimensional
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Summary:The application of fast detectors to microscope mode spatial imaging mass spectrometry, in which the two-dimensional distributions of particular ion masses over a sample are projected onto a two-dimensional detector, allows the imaging of all mass peaks desorbed from a sample on each time-of-flight cycle. Detecting all fragments per duty cycle means that fewer ionisation and acquisition cycles are required for a full set of data, leading to a reduction in overall detection time, amount of sample required, and sample degradation. Results from a proof-of-concept experiment, in which a fast frame transfer charge-coupled device camera (CCD) with 10 ns time resolution was coupled to a modified velocity-mapped imaging apparatus, are presented.
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ISSN:1748-0221
1748-0221
DOI:10.1088/1748-0221/6/01/C01044