Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33

• Published in: Molecular psychiatry Vol. 9; no. 1; pp. 87 - 92
• Main Authors: Chen, Y-S, Akula, N, Detera-Wadleigh, S D, Schulze, T G, Thomas, J, Potash, J B, DePaulo, J R, McInnis, M G, Cox, N J, McMahon, F J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2004; Nature Publishing Group
• Subjects: Adult and adolescent clinical studies; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Bipolar disorder; Bipolar Disorder - genetics; Bipolar disorders; Case-Control Studies; Chromosomes; Chromosomes, Human, Pair 13; Family medical history; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Humans; Independent sample; Linkage Disequilibrium; Medical sciences; Medicine; Medicine & Public Health; Mental disorders; Mental health; Mood disorders; Neurosciences; original-research-article; Pharmacotherapy; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Schizophrenia; United States > US; mood disorder; genetics; allele frequency; Mood disorder; Human; Polymerase chain reaction; Investigation method; Healthy subject; Microsatellite DNA; Genetic linkage; Bipolar disorder; Haplotype; Comparative study; Polymorphism
• ISSN: 1359-4184; 1476-5578
• DOI: 10.1038/sj.mp.4001453

Markers near the nested genes G72 and G30 on chromosome 13q33 have been implicated in the etiology of schizophrenia and, recently, bipolar affective disorder (BPAD). Hattori et al (2003) reported that single-nucleotide polymorphisms (SNPs) near the G72/G30 locus were associated with BPAD in a sample of 22 pedigrees, and that SNP haplotypes were associated in a second, larger sample of triads. The present study attempts to replicate this finding in an independent case–control sample. Six SNPs near the G72/G30 locus, including the most strongly associated markers in the previous study, were tested in 139 cases and 113 ethnically matched controls. Significant association was detected between BPAD and two adjacent SNPs (smallest P =0.007; global P =0.024). Haplotype analysis produced additional support for association (smallest P =0.004; global P =0.004). Analysis of 31 unlinked microsatellite markers detected no population stratification in the cases or controls studied. Although the associated alleles and haplotypes differ from those previously reported, these new results provide further evidence, in an independent sample, for an association between BPAD and genetic variation in the vicinity of the genes G72 and G30.