Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs

Two herpes simplex virus type 1 ribonucleotide reductase null mutants, hrR3 and ICP6Δ, produced cutaneous lesions in guinea pigs as severe as those of wild-type strains. The lesions induced by hrR3 resulted from in vivo replication of the mutant virus, suggesting that this virus-encoded enzyme is no...

Full description

Saved in:
Bibliographic Details
Published inVirology (New York, N.Y.) Vol. 173; no. 2; pp. 733 - 735
Main Authors Turk, Steven R., Kik, Natalie A., Birch, Gary M., Chiego, Daniel J., Shipman, C.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 01.12.1989
Elsevier
Subjects
Animals
Biological and medical sciences
Cell Line
Disease Models, Animal
Experimental viral diseases and models
Female
Guinea Pigs
Herpes Simplex - microbiology
Histocytochemistry
Infectious diseases
Medical sciences
Mutation
Ribonucleotide Reductases - genetics
Simplexvirus - enzymology
Simplexvirus - genetics
Simplexvirus - physiology
Skin - pathology
Viral diseases
Virus Replication
Skin disease
Enzyme
Herpesviridae
Alphaherpesvirinae
Rodentia
Herpes
Histology
Infection
Virus
Vertebrata
Experimental disease
Mammalia
Guinea pig
Herpesvirus hominis 1
Viral disease
Animal
Skin
Mutation
Ribonucleoside-diphosphate reductase
Online AccessGet full text

Cover

More Information
Summary:Two herpes simplex virus type 1 ribonucleotide reductase null mutants, hrR3 and ICP6Δ, produced cutaneous lesions in guinea pigs as severe as those of wild-type strains. The lesions induced by hrR3 resulted from in vivo replication of the mutant virus, suggesting that this virus-encoded enzyme is nonessential for virus replication in guinea pigs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0042-6822
1096-0341
DOI:10.1016/0042-6822(89)90588-6