Endovascular image-guided sampling of tumor-draining veins provides an enriched source of oncological biomarkers
Circulating tumor-derived biomarkers can potentially impact cancer management throughout the continuum of care. This small exploratory study aimed to assess the relative levels of such biomarkers in the tumor-draining vascular beds in patients with solid tumors compared to levels in their peripheral...
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Published in | Frontiers in oncology Vol. 13; p. 916196 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
17.03.2023
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Subjects | |
Online Access | Get full text |
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Summary: | Circulating tumor-derived biomarkers can potentially impact cancer management throughout the continuum of care. This small exploratory study aimed to assess the relative levels of such biomarkers in the tumor-draining vascular beds in patients with solid tumors compared to levels in their peripheral veins.
Using an endovascular image-guided approach, we obtained blood samples from peripheral veins and other vascular compartments-including the most proximal venous drainage from solid tumors-from a set of nine oncology patients with various primary and metastatic malignancies. We then interrogated these samples for a panel of oncological biomarkers, including circulating tumor cells (CTCs), exosome-derived microRNAs (miRNAs), circulating tumor DNA (ctDNA) mutations, and certain cancer-related proteins/biochemical markers.
We found substantially higher levels of CTCs, certain miRNAs, and specific ctDNA mutations in samples from vascular beds closer to the tumor compared with those from peripheral veins and also noted that some of these signals were altered by treatment procedures.
Our results indicate that tumor-proximal venous samples are highly enriched for some oncological biomarkers and may allow for more robust molecular analysis than peripheral vein samples. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Zaver Bhujwalla, School of Medicine, Johns Hopkins University, United States This article was submitted to Cancer Imaging and Image-directed Interventions, a section of the journal Frontiers in Oncology Reviewed by: Harriet Wikman, University Medical Center Hamburg-Eppendorf, Germany; Nikolas Hendrik Stoecklein, University Hospital Düsseldorf, Germany |
ISSN: | 2234-943X 2234-943X |
DOI: | 10.3389/fonc.2023.916196 |